The Syrris range of batch and flow chemistry products has been used in a number of cutting-edge studies and scientific breakthroughs. Below is a list of publications involving reagentless chemistry performed with our products.
- Continuous-flow Electrosynthesis of Selenium-substituted Iminoisobenzofuran via Oxidative Cyclization of Olefinic Amides and Diselenides
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The Longer Route can be Better: Electrosynthesis in Extended Path Flow Cells
Product used: Asia FLUX
The author of this publication gives a personal account describing an overview of work conducted to develop flow electrolysis cells and apply these cells in organic electrosynthesis. It highlights the work performed on the Asia FLUX module, including its development.
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Application of Reactor Engineering Concepts in Continuous Flow Ahemistry: A Review
Cited product: Asia FLLEX
The adoption of flow technology for the manufacture of chemical entities, and in particular pharmaceuticals, has seen rapid growth over the past two decades with the technology now blurring the lines between chemistry and chemical engineering. Asia FLLEX is cited in this research.
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Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates
Product used: Asia FLUX
The authors developed a method for the synthesis of ureas, carbamates through electrochemistry. The common methods make use of phosgene (very dangerous substance) and this new methodology is very easy to be applied on the scaling-up. The Asia FLUX was used for the electrochemical reactions.
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Enzymatic Electrochemical Continuous Flow Cascade Synthesis of Substituted Benzimidazoles
Product used: Asia FLUX
An Asia Flow Chemistry system, including Asia FLUX, was used to perform a sequential oxidation, via heterogeneous biocatalysis, followed by a ciclization, via electrochemistry, to make benzimidazoles compounds. This process was scaled-up and is relevant to green chemistry.
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Droplet Formation in Oval Microchannels with a Double T Junction: A CFD and Experimental Study
Product used: Asia FLUX
The use of microfluidics can improve the process of droplet formation while reducing energy consumption. This publication provides an evaluation of an Asia 1 mL microreactor. The authors used Asia pumps, heater, and microreactor to test a model for generating droplets.
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High-Throughput Electrochemistry: State of the Art, Challenges, and Perspective
Product used: Asia FLUX
Electrochemical transformations involve complex parameter interactions, ranging from universal chemistry variables such as solvent and reagents to specialist factors including electrode material and current density. Hence, the development of a robust and scale-independent electrochemical reaction can currently be a challenge. This paper features Asia FLUX.
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Electrochemistry in Flow for Drug Discovery
Product used: Asia FLUX
Electrochemistry, first proposed over two centuries ago, is one of the oldest forms of reaction set-ups explored in a laboratory. Electrochemical methods possess many benefits in comparison with traditional reagent-based transformations, such as (1) innate scalability and sustainability, (2) high functional group tolerance, (3) mild reaction conditions, (4) high versatility and the ability to carry out reactions that were otherwise inaccessible. This paper features Asia FLUX.
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Electrochemical N-Demethylation of 14-Hydroxy Morphinans – Sustainable Access towards Opioid Antagonists
Product used: Asia Syringe Pump
The authors of this paper used the Asia Syringe Pump in their system to transform an opioid compound into an nor-opioid; a N-demethylation reaction.
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Influence of temperature on the electrochemical window of boron doped diamond: a comparison of commercially available electrodes
Product used: Asia Syringe Pump
In this paper, the researchers used an Asia Syringe Pump to drive solutions into a flow cell to test the influence of temperature in the electrochemistry reactions boron diamond doped electrodes (BDD).
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Pushing the Boundaries of C–H Bond Functionalization Chemistry using Flow Technology
Product used: Asia FLUX
A paper about C-H bond functionalization using flow processes. C-C bond formation using catalysis. It cites Asia FLUX for the elecrochemical synthesis of pirrolidines.
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Electrochemistry in Continuous Systems
Cited product: Asia FLUX
The use of continuous flow conditions for synthetic electrochemical reactions exhibits many benefits over more traditional batch conditions. This is a perspective review about electrochemistry under continuous flow. Syrris are cited as a flow electrochemistry supplier.
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Review - The Design, Performance and Continuing Development of Electrochemical Reactors for Clean Electrosynthesis
Cited product: Asia FLUX
For more than sixty years, markets and hierarchies have dominated our thinking about economic organization. This paper suggests that a third form, the ecosystem organizational form, has now become so important in practice that it should be accorded equal recognition in theory and in policy-making. Syrris are cited as a flow electrochemistry supplier.
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Electrolysis Cells for Laboratory Organic Synthesis
Product used: Asia FLUX
Review about flow electrosynthesis, focused on the flow cell design as a main driver for selectivity, are of conversion and final yield.
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Making Electrochemistry Easily Accessible to the Synthetic Chemist
Cited product: Asia FLUX
A tutorial review about electrochemistry under continuous flow. Syrris are cited as a flow electrochemistry supplier.
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Continuous photochemical benzylic bromination using in situ generated Br2: process intensification towards optimal PMI and throughput
Related product: Asia Photochemistry Reactor
The detailed development of photochemical benzylic brominations using a NaBrO3/HBr bromine generator in continuous flow mode is reported in this paper. Optimization of the bromine generator enables highly efficient mass utilization by HBr recycling, coupled with fast interphase transfer within a microstructured photochemical reactor (405 nm LEDs).
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The Continuous-flow Electrosynthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones from N-alkyl-N-methacryloyl benzamides Under Metal-free and Oxidant-free Conditions
Product used: Asia FLUX
An efficient and green electrochemical continuous flow approach has been developed for the synthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2 H ,4 H )-diones through sulfonylation of alkenes under metal-free and oxidant-free conditions. Asia FLUX was used to perform reactions in this research.
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A Chemoselective and Scalable Transfer Hydrogenation of Aryl Imines by Rapid Continuous Flow Photoredox Catalysis
Product used: Asia Syringe Pumps
In this paper, the authors disclosed a visible light photoredox method for the catalytic transfer hydrogenation of diaryl-ketimines. The process utilises triethylamine as a highly economical single source of electron, proton and hydrogen atom. The reaction was characterised by high product yields, fast reaction times and visible light as the solitary energy source. Asia Syringe Pumps were used was used to perform reactions in this research.
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Electrochemical and Scalable Dehydrogenative C(sp3)−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow
Product used: Asia FLUX
This paper describes the use of electrochemistry to direct amination reactions and the synthesis of a small organic library compound. Asia FLUX was used to perform reactions in this research.
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Electroorganic Synthesis under Flow Conditions
Cited product: Asia FLUX
A review about the application of electrochemistry on the synthesis of organic compounds. This paper cites Asia FLUX.
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Visible light induced regioselective C5 halogenation of 8-aminoquinolines with 1,3-dihalo-5,5-dimethylhydantoin in continuous flow
Product used: Asia Flow Chemistry System
The authors of this paper induced a remote halogenation at the position C5 of quinoline compounds using flow photochemistry. They used an Asia Flow Chemistry System in their experiments.
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Advances in Electro- and Sono-microreactors for Chemical Synthesis
Product used: Asia FLUX
A review paper about the state-of-art of flow electrochemistry and flow sonochemistry. The Asia FLUX and FRX are cited, including some figures.
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Electrosynthesis in Continuous Flow
Cited product: Asia FLUX
Organic electrosynthesis is recognized as a green enabling methodology to perform reactions in an efficient and straightforward way. Electrons are used as the reagent to form anionic and cationic radical species from neutral organic molecules, achieving oxidations and reductions and replacing toxic and dangerous reagents. Within this field, the use of microreactors in continuous flow is particularly compatible with electrochemistry because of the convenient advantages of flow over batch.
Asia FLUX is cited in the electrosynthesis chapter of this book.
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Flow Electrolysis Cells for the Synthetic Organic Chemistry Laboratory
Product used: Asia FLUX
Electrosynthesis has much to offer to the synthetic organic chemist. But in order to be widely accepted as a routine procedure in an organic synthesis laboratory, electrosynthesis needs to be presented in a much more user-friendly way. This review paper gives a detailed explanation about the use of electrolysis in organic synthesis and features Asia FLUX.
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Organic Electrosynthesis – A Road to Greater Application. A Mini Review
Cited product: Asia FLUX
A short review paper about flow electrosynthesis. Asia FLUX is cited.
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Enabling Chemistry Technologies and Parallel Synthesis—Accelerators of Drug Discovery Programmes
Cited product: Asia FLUX
There is a pressing need to improve overall productivity in the pharmaceutical industry. Judicious investments in chemistry technologies can have a significant impact on cycle times, cost of goods and probability of technical success. This perspective describes some of these technologies developed and implemented at AbbVie, and their applications to the synthesis of novel scaffolds and to parallel synthesis. Asia FLUX is cited in a chapter of this book.
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Liquid Phase Oxidation Chemistry in Continuous-flow Microreactors
Cited product: Asia FLUX
This review gives an exhaustive overview of the engineering principles, safety aspects and chemistry associated with liquid phase oxidation in continuous-flow microreactors. Asia FLUX is cited.
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N -Heterocyclic Carbene-Mediated Microfluidic Oxidative Electrosynthesis of Amides from Aldehydes
Cited product: Asia FLUX
A flow process for N-Heterocyclic Carbene (NHC)-mediated anodic oxidative amidation of aldehydes is described, employing an undivided microfluidic electrolysis cell to oxidize Breslow intermediates. Asia FLUX is cited in this research.
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Machine-Assisted Organic Synthesis
Cited product: Asia FLUX
This review describes how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors. In the rapidly changing, multivariant environment of the research laboratory, equipment needs to be modular to accommodate high and low temperatures and pressures, enzymes, multiphase systems, slurries, gases, and organometallic compounds. Asia FLUX is cited in this research.
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Understanding the Performance of a Microfluidic Electrolysis Cell for Routine Organic Electrosynthesis
Product used: Asia FLUX
In order for microflow electrolysis cells to make their full contribution to routine laboratory organic synthesis, they must be capable of carrying out reactions with good selectivity and high conversion at a high rate of conversion. Asia FLUX was used to to perform electrochemical reactions in this research.
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Expedient Preparation of Nazlinine and a Small Library of Indole Alkaloids Using Flow Electrochemistry as an Enabling Technology
Product used: Asia FLUX
An expedient synthesis of the indole alkaloid nazlinine is reported in this paper. The researchers used the Asia FLUX module to perform Shono oxidations and generate a small library and Nazlinine.
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Continuous-Flow Microfluidic Electrochemical Synthesis: Investigating a New Tool for Oxidative Chemistry
Product used: Asia FLUX
In this paper, a continuous-flow microfluidic electrochemical device (Asia FLUX) was designed and evaluated as a practical new laboratory tool to facilitate electrochemical synthetic transformations.
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Preparative Microfluidic Electrosynthesis of Drug Metabolites
Product used: Asia FLUX
In vivo, a drug molecule undergoes its first chemical transformation within the liver via CYP450-catalyzed oxidation. The chemical outcome of the first pass hepatic oxidation is key information to any drug development process. Electrochemistry can be used to simulate CYP450 oxidation, yet it is often confined to the analytical scale, hampering product isolation and full characterization.
A very important paper for the drug metabolism, API, and pharma field. Asia FLUX was used for the research.
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TEMPO-Mediated Electrooxidation of Primary and Secondary Alcohols in a Microfluidic Electrolytic Cell
Product used: Asia FLUX
A general procedure for the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated electrooxidation of primary and secondary alcohols modified for application in a microfluidic electrolytic cell is described in this paper. Asia FLUX was used to generate TEMPO mediated radicals for alcohol oxidations.
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The Methoxylation of N-formylpyrrolidine in a Microfluidic Electrolysis Cell for Routine Synthesis
Product used: Asia FLUX
This paper describes the application development of a high-yielding, high-throughput N-formylpyrrolidine methoxylation reaction carried out in a flow electrochemical cell. Asia FLUX was used to perform reactions in this research.
