Nanoparticle synthesis

What are nanoparticles and what are they used for?

A nanoparticle is defined as a particle of matter that is between 1 and 100 nanometers in diameter. Due to their submicroscopic size, nanoparticles display a range of unique material properties (large surface area/volume ratio, quantum mechanical effects etc), offering a wide range of advantages over regular materials in fields such as medicine, agriculture, engineering, electronics etc.

Fluorescing liquids produced by Syrris Asia

Due to their novel properties, the ability to synthesise nanoparticles with good and controlled qualities is desirable in various fields of application – with the method of synthesis falling into one of two general strategies.

      • Top-down – breakdown or leaching of nanoparticles from bulk material
        • E.g. Milling, ion/plasma etching, lithography
      • Bottom-up – coallesence or assembly of atoms/molecules into nanoparticles
        • E.g. Chemical precipitation, CVD, polymerization

Nanoparticle properties are closely linked to their size, shape, composition and surface structure – therefore accurate control of reaction conditions is key to ensuring nanoparticles with the desired properties. Key synthesis parameters include temperature, mixing, reagent concentrations and reaction time.

Nanoparticle synthesis in batch

Typically, nanoparticle synthesis in batch reactors focus on “wet chemical” processes to form an insoluble precipitate of the desired nanoparticles. The resultant particles are then separated from the solvent by a combination of filtration, centrifugation, washing, sedimentation and evaporation.

Batch processing of nanoparticles is a cost effective and convenient method for nanoparticle synthesis and allows for fine control of the particle’s chemical composition – however care must be taken to ensure batch-to-batch consistency of nanoparticle properties.

Jacketed lab reactors provide an excellent solution for nanoparticle synthesis, offering excellent mixing and pin-point temperature control, as well as the ability to automate your entire procedure (including dosing protocols) for the highest levels of reproducibility.

Multiple sensor can also be used to accurately monitor and control all reaction parameters (temperature, pH, turbidity etc) in real time.

Jacketed lab reactors also simplify the process of scaling nanoparticle synthesis, by utilising common reactor geometries across a large volume range found at manufacturing scale.

Syrris's range of vessel geometries
A photograph of several glass vials, filled with nanoparticles produced on Syrris Asia flow chemistry systems
Nanoparticles produced on Syrris Asia flow chemistry systems
Gold Nanoparticles produced on a Syrris Orb jacketed reactor viewed under a microscope
Gold Nanoparticles produced on a Syrris Orb jacketed reactor viewed under a microscope
Fluorescing liquids produced by Syrris Asia
Fluorescing liquids produced by Syrris Asia

How can Syrris help chemists performing nanochemistry?

Syrris offers a wide range of innovative batch and flow reactors for nanoparticle synthesis. The award-winning systems, designed by chemists for chemists, present multiple benefits:

      • Narrow particle size distribution: Excellent mixing and temperature control leads to improved homogeneity of particle size
      • Rapid nanoparticle optimization: Process conditions such as temperature, time, mixing, reagent ratios and concentrations can be quickly varied
      • Reproducibility and automation: Additions, mixing, temperature, etc. can be fully controlled in an automated fashion for seamless reproducibility
      • Easy to use: All products can be assembled, maintained and cleaned without tools
      • Simple scale up: Large range of reactor sizes (batch) and flow rates (continuous flow) provides the tools for moving from small-scale process optimization to production
      • Nanoparticles not possible by other means: Nanoparticles previously unseen using batch techniques can be obtained in microreactors due to the high level of control

The list below shows a selection of nanoparticles synthesized in Syrris reactor systems and the unique advantages they have offered:

Nanoparticle Synthesised Unique advantage using Syrris reactor systems
Nickel nanocubes Ability to accurately select the desired shape. High-quality material obtained
Silver nanowires Excellent monodispersity. Improved electric conductivity property
Gold nanocrystals Smaller average particle size obtained in flow. Easy process optimization
Silica beads Narrow size distribution. High reproducibility
Platinum nanoparticles deposited on carbon fibers Synthesis and deposition performed in one cycle. Control of the size by varying flow rate
Cadmium selenide quantum dots Synthesis, capping, and functionalization is done in one continuous process. Large-scale synthesis
Superparamagnetic iron nanoparticles Small particle size. Fast throughput
Nickel tetrapods Previously unreported shape. Only seen in microreactors
Titanium oxide nanoparticles Faster synthesis. Excellent yields
Amino-functionalized graphene quantum dots couple with gold nanoparticles Coupled amino-functionalised graphene quantum dots to gold nanoparticles in batch.
Iron nanoparticles Large scale batch synthesis. Atlas pump used for reagent dosing.
Magnetic iron nanoparticles Used externally mounted magnetic rods for particle separation

Nanoparticle synthesis customer stories

The Orb system is very simple to operate, compact and robust” says Prof. Aucelio. “We are using it for the synthesis of gold nanoparticles (AuNPs) capped with different chemical binders. As the system is very easy to operate, my masters´ and doctoral students already have full autonomy to use the system.”

Reproducible scaling of Gold nanoparticles in Brazil

Researchers at a University in Brazil have been using the Orb Jacketed Reactor system to scale up their gold nanoparticle synthesis.  Prof. Ricardo Aucélio from Pontificia Universidade Católica research looks at specialist nanoparticles for use in analytical tools.  They purchased the Orb system in an attempt to overcome the scaling issues of moving from a round bottom flask.


The Atlas Potassium was the only logical way to move from manufacturing nanoparticles on a laboratory scale to a mini production environment.”

Justin Barry, CEO, Midatech

Midatech use Atlas reactors to produce gold nanoparticles for pharmaceutical applications

Midatech Biogune, a Spanish biotechnology company, are using Syrris Atlas automated jacketed reactor systems to produce custom-made functionalized gold nanoparticles for medicinal use.

Read the full customer story here

Nanoparticle synthesis publications

Syrris products have been used for the synthesis and study of various nanoparticles including:

Nanoparticle synthesis in batch chemistry publications

Large-Scale Synthesis of Colloidal Fe3O4 Nanoparticles Exhibiting High Heating Efficiency in Magnetic Hyperthermia

First published: 2nd April 2014 |

This paper used Atlas jacketed lab reactor to synthesise iron nanoparticles on large scale, using Atlas pump to dose reagents.

Determination of Aflatoxin M1 in Milk by a Magnetic Nanoparticle-Based Fluorescent Immunoassay

First published: 17 Jan 2017 |

This paper used Globe jacketed lab reactor for the preparation and functionalisation of magnetic nanoparticles.

Preparation of Paraffin-Based Solid Combustible for Hybrid Propulsion Rocket Motor

First published: 02 Dec 2016 |

This paper used Atlas jacketed lab reactor to create paraffin particles with a controlled range of diameters.

Unexpected Secondary Nucleation in Poly(Vinyl acetate) Nanoparticle Synthesis by Ab Initio Batch Emulsion Polymerization Using Poly(Vinyl alcohol) as Surfactant

First published: 13th Aug 2019 |

This paper used Atlas jacketed lab reactor for emulsion polymerisation to produce polymer nanoparticles.

Nanoparticle synthesis in flow chemistry publications

Green microfluidic synthesis of monodisperse silver nanoparticles via genetic algorithm optimization

Using the Syrris Asia system, researchers at the Department of Chemistry (Uppsala University, Sweden) have reported the scalable and green synthesis of monodisperse silver nanoparticles via genetic algorithm optimization.

Green microfluidic synthesis of monodisperse silver nanoparticles via genetic algorithm optimization

First published: 23rd July 2015 |

This publication uses an Asia flow chemistry system.

Sensitive progesterone determination using a magnetic particle-based enzyme-linked immunosorbent assay

This publication describes the synthesis, silane functionalization and use of magnetic Iron nanoparticles in combination with enzyme-linked immunosorbent assay (ELISA) to facilitate the hybrid technique of ‘magnetic nanoparticles – ELISA’ for use in the capture of progesterone in numerous types of milk. The synthesis and functionalization of the magnetic nanoparticles were carried out in an automated Globe system (now replaced by the Syrris Orb Jacketed Reactor) to furnish nanoparticles with a mean size of 182.4nm and 292.8nm after functionalization.

First published online: 24th November 2014 |

Nickel nanocrystals – fast synthesis of cubes, pyramids, and tetrapods

In this paper, the authors study the formation and growth of nickel nanocrystals/nanoparticles using organometallic Ni(η4-C8H12)2 as a precursor. The reaction temperature has been identified as the key parameter which determines the shape of the obtained nanoparticles. In addition to the three classic shapes of nanoparticles (cubical, spherical, pyramidal), a new shape of nanoparticles – tetrapods – has been reported. This shape has only been observed in Syrris microreactors because of the excellent heat transfer and temperature control obtained in those devices.

Nickel nanocrystals: fast synthesis of cubes, pyramids and tetrapodsNickel nanocrystals: fast synthesis of cubes, pyramids and tetrapods

First published: 12st November 2012 |

This paper uses an Asia flow chemistry syringe pump and a glass microreactor.

See the full list here

Discuss your nanoparticle chemistry with a Syrris chemist

Further reading

Crystallization monitoring and control with the Syrris Atlas HD Crystallization system Crystallization is defined as a process by which a […]
Sonocrystallization applications
What is Sonocrystallization? Sonocrystallization is the application of ultrasound energy to control the nucleation of a crystallization process. Applying Ultrasound […]
Flow vs. batch chemistry
What are the differences between flow chemistry and traditional batch chemistry? Chemistry performed in a flow reactor can be used […]
Flow chemistry
What is flow chemistry? “Flow chemistry”, sometimes referred to as “plug flow”, “microchemistry”, or “continuous flow chemistry” is the process […]

Syrris products used in nanoparticle synthesis and nanochemistry