Publication – Multistep continuous preparation of chiral O-acetyl-cyanohydrins

Synlett. 2016, 27(2), 262-266, DOI: 10.1055/s-0035-1560644

Aischarya Brahma^a,b, Biagia Musio^b, Uliviya Ismayilova^c, Nikzad Nikbin^b, Sonja B. Kamptmann^b, Petra Sieger^c, Günter E. Jeromin^c, Steven V. Ley^b, Martina Pohl^a

• ^aaIBG-1: Biotechnology, Jülich, Germany
• ^bbDepartment of Chemistry, University of Cambridge, Cambridge
• ^cInstitute of Nano- and Biotechnologies (INB), Aachen University of Applied Sciences, Germany

Using Syrris Asia Syringe Pumps researchers at the Dept. of Chemistry (University of Cambridge), IBG-1: Biotechnology (Germany) and INB (Aachen University of Applied Sciences) have demonstrated an enantioselective preparation of O-Acetyl-cyanohydrins in a three-step telescoped continuous process.

The modular components enabled an accurate control of two sequential biotransformations, safe handling of an in situ generated hazardous gas and inline stabilization of products.

This method proved to be advantageous over the batch protocols in terms of reaction time (40 min vs 345 min) and ease of operation, opening up access to reactions which have often been neglected due to safety concerns.

Abstract: An enantioselective preparation of O-acetyl-cyanohydrins has been accomplished by a three-step telescoped continuous process. The modular components enabled an accurate control of two sequential biotransformations, safe handling of an in situ generated hazardous gas and inline stabilization of products. This method proved to be advantageous over the batch protocols in terms of reaction time (40 min vs 345 min) and ease of operation, opening up access to reactions which have often been neglected due to safety concerns.

This paper uses the Asia Syringe Pumps.

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