Publication – Facile, fast and safe process development of nitration and bromination reactions using continuous flow reactors
Org. Process Res. Dev., 2009, 13 (4), pp 698–705
- Jacques Pelleter* and Fabrice Renaud
- AstraZeneca, Centre de recherches, Z. I. La Pompelle, BP1050, 51689 Reims cedex 2, France
Abstract: Chemists working in a pilot plant often face safety issues during scale-up operations. With the help of emerging microfluidic applications and microdevices, running hazardous, highly exothermic or potentially unstable reactions can be easily transposed into a safe continuous flow mode. This paper describes how a potentially hazardous pyrazole nitration and the bromination of a variety of electron-rich heteroaromatic substrates were efficiently performed using a cheap and easily available system for bench chemists. Advantages of the continuous flow mode in organic synthetic chemistry will be exemplified by the large-scale production of raw materials under safe, green and reproducible conditions.
This paper was published using the Syrris Asia Syringe Pumps.