Process intensification for tertiary amine catalyzed glycerol carbonate production

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RSC Adv. 2015, 5, 20945-20950, DOI: 10.1039/C5RA02117K

Daniel O. Nogueira, Stefania P. de Souza, Raquel A. C. Leao, Leandro S. M. Miranda and Rodrigo O. M. A. de Souza

Biocatalysis and Organic Synthesis Group, Chemistry Institute, Universidade Federal do Rio de Janeiro, Bloco A 622, Rio de Janeiro, RJ 21941-909, Brazil

In this paper, de Souza’s group present an efficient method for synthesizing glycerol carbonate from glycerol. The chosen synthetic route was first tried and optimized on a small scale using microwave irradiation then transferred onto the Asia Discovery System Advanced for scaling up. Under solvent-less continuous-flow, 80% yield and 82% selectivity was observed in 16 minutes residence time. These conditions allowed production of glycerol carbonate at a 24 kg/L/day rate.

Abstract: Different products of interest can be produced from glycerol and glycerol carbonate (GC) has received much attention in recent years because of its physical properties, nontoxicity, and water solubility. Herein we report a process intensification protocol for glycerol carbonate production mediated by tertiary amine catalysis where a 24 kg per L per day productivity was obtained with 79% isolated yield and a 5 hour operation time without losing efficiency.

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This paper uses the Asia Discovery System Advanced. Learn more about the product this chemistry was performed on:

Asia Discovery System

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