Fluorination reactions in microreactors

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Chem. Commun., 2008, 3022-3024

  • Tomas Gustafsson, Ryan Gilmour, and Peter H. Seeberger*
  • Swiss Federal Institute of Technology, Zurich, Laboratorium für Organische Chemie, Switzerland

This paper describes a fast, safe and continuous fluorination protocol using DAST for primary alcohols, carboxylic acids, and aldehydes conducted in a Syrris Tube Reactor on a Syrris FRX system (now replaced by Asia).


Abstract: The DAST-mediated conversion of a range of alcohols to the corresponding fluorides in a microstructured device is described. This safe, practical fluorination method will facilitate reactions currently challenging on large scale.

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This paper used an FRX flow chemistry system (now replaced by Asia).