The full (SAHF) AFRICA System enables entirely automated flow synthesis, analysis, aqueous work up, reagent injection and product collection.
This system enables hundreds of compounds (separated by solvent) to be injected into sample loops then pumped into the flow reactor under pressure, reacted, worked-up, sampled/diluted, analysed by HPLC and collected into vials. Reaction conditions such as time, temperature and reagent equivalents can be varied automatically before flowing the output to the HPLC and aqueous work up system.
Multiple reactions can be injected into the flowing stream in a fast serial fashion so that several reactions are in the system at a time.
The injection timing of up to four components per reaction is fully controlled by the software to ensure samples meet in the reactor(s) at the correct time.
Lists of reagents/substrates can be imported into the software from .csv files and their volume tracked during use enabling full resource management.
This system is suited to the following applications: synthetic libraries, reagent screening, reaction optimisation, kinetic studies, degradation studies, logD screening, aqueous work-up screening etc.
AFRICA Systems:
A table of AFRICA systems and the modules they contain is shown below.
*Note that the Heater/Cooler can be subsituted by the Flow Factory
