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Reagent Injection

Reagent Injection

The Reagent Injection Modules consist of a Gilson autosampler, RIM:Feed (Reagent Injection Module:Feed) and RIM:Loops (Reagent Injection Module:Loops). 

Together they enable hundreds of compounds to be injected into the flow reactor under pressure, separated by a solvent analogous to bullets down the barrel of a machine gun.  The Reagent Injection Modules can inject multiple reactions into the flowing stream in a fast serial fashion so that several reactions are in the system at a time.

The injection timing of up to four components per reaction is fully controlled by the software to ensure samples meet in the reactor(s) at the correct time. 

Lists of reagents/substrates can be imported into the software from .csv files and their volume tracked during use enabling full resource management.

These modules are suited to the following applications: synthetic libraries, reagent screening, reaction optimisation, kinetic studies, degradation studies, logD screening etc.

Gilson GX-271  Industry standard, reliable autosampler capable of accessing 100s of substrates/reagents.  This is modified with a custom coaxial needle to enable septum piercing and aspiration of air sensitive reagents.  The deck can be configured by the customer to accept custom arrangements of vials and/or bottles.
RIM:Loops The RIM:Loops module contains 4 chemically resistant injection valves each with two 1ml sample loops attached.  These can be used to inject as little as 100µl at a time or multiples of 1ml back to back as one loop can be filled while the other is emptied.  The sample loops are actively pressurised to the reactor pressure before injection to maintain sample control and maintain pressure (e.g. when heating reactions 100°C above reflux).
RIM:Feed The RIM:Feed module provides the communications link between the PC and the Gilson robot and the fluidic connection between the robot and the RIM:Loops module.  It also enables the RIM:Loops module to aspirate directly from pressurised bottles rather than via the robot if desired.







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