The FRX system from Syrris makes flow chemistry cost effective, easy to use, understandable and affordable. FRX is made up of a number of modules that can be connected together to form simple yet powerful flow chemistry systems.
FRX Benefits
Faster reactions: Increase reaction rates over 100 fold by superheating reactions significantly above reflux e.g. dichloromethane to 100°C, acetonitrile to 150°C and water to 170°C.
Cleaner reactions: Reduced impurities via excellent, reproducible reaction control and optional use of solid phase reagents/catalysts/scavengers.
Inline aqueous work-up: The Flow Liquid Liquid Extraction Module (FLLEX) enables two immiscible phases to be mixed and separated in flow, immediately following the reaction.
Safer reactions: Only small amounts of material react at any time, minimising exotherms and the quantity of any hazardous intermediates.
Rapid development: Reaction time, temperature and equivalents can be rapidly varied using mg of substrate.
Scale-up: Production rates up to kg overnight. Wide temperature range: Heat reactions up to 200°C or cool down to -20°C.
Chemically resistant: Glass and PTFE reactors allow a wide range of chemistry.
Compact size: FRX systems fit easily into standard fume cupboards.
FRX Systems
All the FRX systems are intuitive and easy to use, without the need for tools. The configuration of a system can be changed in seconds to meet the needs of different reactions.
FRX100 is an entry level set-up designed to give users an introduction to flow chemistry and combines the performance of the FRX™ pumps with a 4ml tube reactor (small enough for reaction development but large enough for preparative experiments). The system contains a pressure controller, to allow operation above solvent boiling points, and a collection tool to collect different fractions of products as reaction conditions change.
FRX200 combines a range of reactors (micro reactors, tube reactors and solid-phase columns) with sample addition and collection. This system provides the ideal environment for looking at scale-up within flow reactors and enables initial development with small scale reactors with preparative reaction conducted on larger scale. The inclusion of solid phase columns allows solid supported reagents, scavengers and catalysts to be used.
FRX300 is a complete workstation giving any chemist a wide range of experimental possibilities with flow reactions. By including the FLLEX™, liquid-liquid extraction module the FRX300 allows materials to be prepared and worked up automatically.
FRX400 is the largest and most versatile FRX™ system allowing heating and cooling with online work-up and reaction volumes from 62µl to 16ml.
A flyer detailing the systems and modules which comprise FRX™ is available to registered users in the downloads section. Some other documents which may be of interest are included below and an application note is available which describes the experiments conducted in the videos - contact us for details.
