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The Atlas SonoLab is a high performance, automated ultrasound system for sonocrystallization, sonomilling and sonochemistry. The proprietary ultrasound technology with novel transducer based design, allows reproducible control of crystallizations, enabling selectivity of parameters such as particle size, shape, crystallinity and polymorphism.

Atlas SonoLab benefits Selective: Significantly improved polymorph, particle       size and particle shape selectivity. Narrow particle size distribution: Advanced control       of nucleation and growth rate results in very narrow       particle size distribution. High purity: Sophisticated control results in reduced      impurities and trapped solvents. Reproducible: Automated control of process       parameters and nucleation improves batch to batch      consistency. Scalable: Optimised crystallizations on a laboratory       scale can be scaled to pilot plant processes and       manufacturing using the Prosonitron™ range of      products from Prosonix Ltd. Product quality improvement: Improved formulation      consistency, stability and performance of final drug      products. No seeding required: Removing the need for seed       crystals avoids issues with consistency and access to      the reactor. Easy to use: No tools required, intuitive “drag and drop”      Atlas software and real time data graphed during      process. Excellent temperature control: Sophisticated PID      temperature control and accurate sensor feedback      results in accurate process performance. Advanced automation: With the Atlas PC software,      the system can introduce ultrasound at accurate       temperature points within and around the metastable       zone. Integrated turbidity or FBRM analysis: The Atlas      Software allows integration of the Syrris Turbidity Probe      or FBRM characterization. What is Sonocrystallization? Sonocrystallization is the application of high intensity, low frequency ultrasound to your process, resulting in acoustic cavitation of the solution.  Controlled cavitation allows extremely accurate control of nucleation, a process which is random and very difficult to control by conventional techniques.

The Atlas SonoLab system is based on Syrris’ Atlas Potassium System for jacketed vessels with the addition of the Prosonix proprietary ultrasonic flow cell, generator and pump. The powerful Atlas Software allows full control of all the important parameters required for sonocrystallization, sonomilling and sonochemistry applications: Crystallization            - Automated metastable zone width studies           - Optimisation of product recovery - crystal size,               purity and recovery           - Complete control of crystallization using pulsed or               continuous insonation Scale-up            - Batch-to-batch repeatability            - Seamless scale to pilot plant and beyond using              Prosonitron™ Polymorphism            - Impact of different solvents, mixtures,               concentrations and temperatures           - Selective polymorph control without seeding Milling Studies           - Removal of conventional wet milling steps           - Reduced fines compared to wet milling An Atlas SonoLab System contains: