Flow chemistry systems can not only perform reactions on a small scale for optimisation but once the preferred conditions are known, the flow rate can be increased to produce hundreds of grams of product. Due to reactor volumes of up to 16ml and flow rates of 2.5 ml/min per input, reaction scales in the order of litres can be synthesised overnight. The FRX system is ideal for production of larger quanties of material in flow reactors.
The following nucleophilic aromatic substitution was performed using the AFRICA system to synthesise 50g of product in 24hrs. The reaction was performed at 150ºC despite the atmospheric boiling point of the solvent being 100ºC using pressurisation and, therefore, the superheating capability.
