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To synthesise a consistent sized nanoparticle and/or to produce a consistent covalently derivatised particle it is essential to have:
- Excellent control of conditions:
- No temperature gradients
- No concentration gradients
- Efficient and controlled mixing
This ensures a constant rate of reaction throughout the reactor and therefore a consistent nanoparticle – microreactors achieve this every time.
Segmented flow in microreactors can also be used as a method to combat dispersion along channels and to promote mixing (Tice, J.D. et al. Langmuir 2003 19, 9127-8133).
Features of a continuous microreactor system
1.Precise control of temperature – easily set and changed - no temperature gradients
2.Precise control of time - easily set and changed – quick hot reactions for consistent particle size
3.Precise control of feeds/stoichiometry – rapidly investigate stoichiometry by changing feed rates
4.Consistent and rapid mixing – ensures nucleation not precipitation
5.No scale limitations – small scale for optimisation; or “leave tap running” to make kilograms per day (100g/hr readily achievable)
6.Reproducible – same temperature, same mixing, same reaction time, every time
7.Immediate aqueous work up – simple work up available if required |
