Log D determination

Log D is the ratio of the equilibrium concentrations of all species (unionized and ionized) of a molecule in octanol compared to same species in the aqueous phase at a standard temperature (normally 25° C). It differs from LogP in that ionised species are considered as well as the neutral form of the molecule.

Click here to see the AFRICA flow system.

Click here to see the FRX flow system.

LogD is defined as:

where the sum is over all species (C) and  the subscripts oct and aq refer to concentrations in the aqueous and organic phases.

Syrris utilise FLLEX within an AFRICA system to separate the aquous and octanol phases after partitioning between the phases is complete.

The Syrris Africa LogD system

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The Dolomite Centre provides design, development and manufacture of glass microfluidic devices and systems.